annoyance; upset; be vexed; be worried
Don't be upset by trifles.; Don't worry over trifles.
It bothered me that boys weren't interested in me
Donating time and energy to others can take you out of yourself.
I worried for ages and decided that I had better break it to her.
Is anything troubling you?
It does not bother me now at all. It is all ancient history.
They come to me to whine about their troubles.
She tells me her troubles. I tell her mine
Let's forget about those worries.
I realise now that the things which used to niggle and annoy me just don't really matter
He did not tell his relatives and friends about his woes.
I'd rather let him stew
He was disturbed by the inaccuracy of the answers
Spots can be the bane of a teenager's life.
Tony was unnerved by the uncanny familiarity of her face.